2-Acetyl-3-methylpyrazine (CAS 23787-80-6, FEMA 3964)

2-Acetyl-3-methylpyrazine: The Essence of Roasted and Nutty Profiles

2-Acetyl-3-methylpyrazine (CAS 23787-80-6) is a heterocyclic organic compound belonging to the pyrazine family, renowned for its powerful and characteristic organoleptic properties. This volatile compound is a significant contributor to the flavor and aroma profiles of various thermally processed foods, making it a highly valuable substance in the flavor and fragrance industries. Recognized globally for its safety and efficacy, it holds the FEMA number 3964 and is evaluated by JECFA under the flavor number 950 .

Chemically identified by the molecular formula C₇H₈N₂O and a molecular weight of 136.15 g/mol, 2-Acetyl-3-methylpyrazine presents itself as a clear liquid, typically ranging in color from light yellow to orange . Its defining characteristic is its intense, complex aroma. At usage levels, it imparts a distinct nutty, roasted, and savory character, often described as reminiscent of popcorn, corn chips, roasted peanuts, coffee, and cocoa . This potent sensory profile allows it to function effectively even at low concentrations, adding depth and authenticity to flavor formulations.

The primary application of 2-Acetyl-3-methylpyrazine is as a flavoring agent or adjuvant . It is expertly utilized to recreate or enhance savory and gourmand notes in a wide array of products. Common food applications include baked goods, breakfast cereals, snack foods, confectionery, dairy products, and meat or savory sauces . By mimicking the aroma of freshly roasted or baked goods, it bridges the gap between natural and processed flavors, providing a consistent and desirable sensory experience.

Beyond the food sector, this compound is equally important in the fragrance industry. Its warm, nutty, and slightly earthy scent profile adds complexity and warmth to fine fragrances and personal care products such as lotions and creams . Research indicates that 2-acetyl-3-methylpyrazine occurs naturally in a variety of food items, including cocoa, coffee, pork, lobster, and potato products, confirming its integral role in the natural flavor chemistry of cooked foods .

In research and development, 2-acetyl-3-methylpyrazine (CAS 23787-80-6) serves as a critical standard for analytical chemistry, particularly in gas chromatography (GC) and mass spectrometry (MS) for foodomics and metabolomics studies . Its distinct structure also makes it a subject of interest in medicinal chemistry and materials science for the synthesis of more complex molecules . Safety assessments have been conducted by reputable bodies, including the Research Institute for Fragrance Materials (RIFM), which confirms its safe use in cosmetic and fragrance applications under current maximum concentration limits, with no genotoxicity concerns identified . Whether you are a flavorist crafting the perfect savory note, a perfumer seeking depth, or a researcher studying volatile organic compounds, 2-Acetyl-3-methylpyrazine (FEMA 3964) is an indispensable tool for achieving authentic and high-impact results.