ʻO Thiophene-2-thiol: He Molekula Versatile no nā noi ʻala a me nā lāʻau lapaʻau

ʻO Tiopena-2-tiol, kahi hui heterocyclic i loaʻa ka sulfur, ua hoʻokumu iā ia iho he molekala versatile loa me nā noi e pili ana mai ka hoʻonui ʻono a hiki i ka hoʻomohala ʻana i nā lāʻau lapaʻau. ʻIke ʻia e kekahi mau inoa e like me 2-mercaptothiophene a me 2-thienyl mercaptan, hōʻike kēia hui i nā waiwai kū hoʻokahi e hoʻolilo iā ia i waiwai nui ma nā ʻoihana he nui.

ʻIke Kumu a me ke Kūlana Hoʻoponopono
Nā mea hōʻike kemika: Helu CAS: 7774-74-5; Ke ʻano molekala: C₄H₄S₂; Kaumaha molekala: 116.2 g/mol.

ʻĀpono Hoʻoponopono: Ua ʻāpono ʻia ma ke ʻano he mea ʻono me ka helu FEMA 3062, ka helu FDA 172.515, a me ka helu CoE 478, e hōʻike ana i kona ʻae ʻia ʻana i nā noi meaʻai i loko o nā ʻōnaehana hoʻoponopono.

Nā ʻano huahana
Nā Waiwai Kino a me nā Kemika:

ʻAno: Wai ʻaila ʻole ke kala a melemele māmā (a ʻalani paha).

ʻAno ʻAla: Hōʻike i kahi ʻano ikaika a sulfurous me nā nota caramel i puhi ʻia a me ke kofe i kālua ʻia, ʻoiai ua wehewehe ʻia he ʻala sulfurous i puhi ʻia "ʻoluʻolu ʻole loa" i kekahi mau ʻano.

Ka hoʻoheheʻe ʻia: Hoʻoheheʻe iki ʻia i ka wai akā hiki ke hui pū ʻia me nā mea hoʻoheheʻe organik e like me ka ethanol ma ka mahana o ka lumi.

Nā Kūlana Kino Koʻikoʻi: ʻO ka nui o ka nui ma kahi o 1.24-1.255 g/mL; ka paila ʻana ma kahi o 124-129°C.

Ka Hana Hou: He hui ea e pono ai ka mālama ʻana i ka lewa inert ma 2-8°C. He thiol pane nui loa ia i hiki ke hana i nā pilina covalent ikaika me nā metala like ʻole.

ʻIke Palekana:
Ua hoʻokaʻawale ʻia me nā ʻōlelo hoʻoweliweli GHS e komo pū ana me nā mea ʻino inā moni ʻia (H302), nā mea ʻino i ka wā e pili ana me ka ʻili (H312), a me nā mea ʻino inā hanu ʻia (H332). Hōʻike ka ʻikepili palekana i ka hiki ke hoʻonāukiuki i ka ʻili a me ka maka.

Nā Noi Mua a me ke Kūlana Makeke
ʻOihana ʻAla a me ka ʻAla
Hana ʻo Thiophene-2-thiol ma ke ʻano he mea ʻono koʻikoʻi i nā huahana meaʻai, ʻoi aku hoʻi i:

Nā Mea ʻOno a me nā Mea i Hoʻomoʻa ʻia: Manaʻo ʻia ma nā ʻano haʻahaʻa e like me 0.1 mg/kg i nā huahana meaʻai hope loa.

Hoʻonui i ka ʻono: Hāʻawi i nā ʻono ʻokoʻa i kālua ʻia, e like me ka caramel i nā meaʻai like ʻole.

Nā Noi Lāʻau Lapaʻau
ʻO ka ʻāpana lāʻau lapaʻau kahi wahi noi nui a ulu nei no ka thiophene-2-thiol a me kāna mau mea i loaʻa, ʻo ia hoʻi:

Poloka Hale Hana Hana ʻAno Like ʻOle: Hana ma ke ʻano he waena koʻikoʻi i ka hana ʻana i nā pūhui lāʻau lapaʻau paʻakikī.

ʻO ke kumu hoʻolālā koʻikoʻi i ka ʻike ʻana i nā lāʻau lapaʻau: Ke hoʻonui nui ʻia nei ka waiwai o ka scaffold thiophene no ka hoʻomohala ʻana i nā mea lapaʻau hou.

Ka Hihia Hoʻohana Lāʻau Lapaʻau Koʻikoʻi:
Ua hōʻike ʻia kahi noi lāʻau lapaʻau pololei o nā thiophene-2-thiol derivatives ma Midesteine ​​(MR-889), kahi lāʻau i hoʻomohala ʻia no ka mālama ʻana i ka ʻūhū phlegmy. ʻO kēia lāʻau molekole liʻiliʻi, kahi e hoʻohui i nā mea kūkulu e pili ana i ka thiophene-2-thiol, hana ma ke ʻano he mea hoʻopaʻa neutrophil elastase (NE) kanaka. ʻOiai ua hoʻopau ʻia ka hoʻomohala ʻana i ka wā o nā hoʻokolohua Phase 3, hōʻike kēia laʻana pehea e hiki ai ke hana ʻia nā thiophene derivatives e kuhikuhi i nā ʻano maʻi kikoʻī.

Nā Holomua Noiʻi Anticancer
Ua noiʻi nā haʻawina ʻepekema hou i nā thiophene derivatives e like me nā mea hana anticancer hiki:

Hoʻonohonoho Kūlana: Ua hana nā kānaka noiʻi i nā mea like thiophene hou me ka hana i hōʻike ʻia e kūʻē i nā laina cell cancer ate (HepG2) a me nā laina cell cancer ovarian (A2780 a me A2780CP).

Nā Hopena Hoʻohiki: Ua hōʻike kekahi mau mea i loaʻa mai, e like me kekahi mau hui thienopyridine-carboxamide, i ka hopena like a ʻoi aku paha i nā lāʻau lapaʻau i hoʻokumu ʻia e like me Sorafenib i nā haʻawina mua.

Ka Mana Hana: Hōʻike kēia mau hui i kahi ala hou e hoʻohiki nei i ka hoʻomohala ʻana i nā lāʻau lapaʻau oncology, e hoʻohana ana i ka scaffold thiophene no nā hana therapeutic i hoʻopaʻa ʻia.

Nā Waiwai Biomedical ʻē aʻe
Ma waho aʻe o ka hoʻomohala ʻana i nā lāʻau lapaʻau kikoʻī, hōʻike ka thiophene-2-thiol i kekahi mau waiwai pili olaola:

Nā Hana Antioxidant a me Anti-inflammatory: Ua hōʻike ʻia ma nā noiʻi like ʻole.

Nā hopena antimicrobial: Hōʻike i nā hana antibacterial a me antifungal, e hōʻike ana i ka hiki ke mālama i nā maʻi.

Metal Chelation: Hiki ke hoʻohana ʻia kona hiki ke hoʻopaʻa i nā metala e like me ke keleawe, ke kālā, a me ke gula i ka hoʻolālā ʻana i nā lāʻau lapaʻau i hoʻopaʻa ʻia i ka metala a i ʻole nā ​​​​mea hana diagnostic.

Nā Noiʻi ʻEpekema Mea a me nā Noiʻi
ʻO ka Surface-Enhanced Raman Spectroscopy (SERS): Hoʻohana ʻia ma ke ʻano he probe i loko o ka kemika analytical.

Nā Hana Hoʻoheheʻe ʻia e ka Metala: Hana ma ke ʻano he ligand i nā kaʻina hana catalytic like ʻole.

Ka Nānā ʻana i ke Kaiapuni: Nā noi kūpono i ka hoʻomohala ʻana i nā ʻano hana no ka kaohi ʻana i ka haumia.

Ka Nānā ʻana i ka Pōmaikaʻi Hoʻohālikelike
Nā Pōmaikaʻi Kūikawā o ka Wahi Hoʻohana o Thiophene-2-thiol
ʻO ka Synthesis Pharmaceutical ʻAe nā wahi hana like ʻole i nā hoʻololi kemika like ʻole; hāʻawi ka scaffold thiophene i ka paʻa metabolic a me nā waiwai pharmacokinetic maikaʻi
ʻOihana ʻAla Ka hopena ʻono ikaika ma nā ʻano haʻahaʻa loa (0.1 mg/kg); hāʻawi i nā ʻano sensory ʻokoʻa i hiki ʻole ke kope maʻalahi ʻia e nā hui ʻē aʻe
Noiʻi & Hoʻomohala ʻO ka hana pālua (thiol + heterocycle) e hiki ai i nā noi like ʻole; lawelawe ma ke ʻano he poloka kūkulu no nā mea hou a me nā pūhui bioactive