I-Thiophene-2-thiol: Imolekyuli Enemisebenzi Ehlukahlukeneyo Yevumba Nezicelo Zamayeza

I-Thiophene-2-thiol, i-compound ene-heterocyclic equlethe i-sulfur, izibonakalise njengemolekyuli eguquguqukayo kakhulu enezicelo eziqala ekuphuculeni incasa ukuya kuphuhliso lwamayeza. Eyaziwa ngamagama aliqela kuquka i-2-mercaptothiophene kunye ne-2-thienyl mercaptan, le compound ibonisa iimpawu ezikhethekileyo ezenza ukuba ibe luncedo kumashishini amaninzi.

Ulwazi oluSiseko kunye neMeko yoLawulo
Izinto ezichonga iikhemikhali: Inombolo ye-CAS: 7774-74-5Ifomula yeMolekyuli: C₄H₄S₂; Ubunzima beMolekyuli: 116.2 g/mol.

Imvume Elawulayo: Ivunyiwe njengearhente yokunambitha enenombolo ye-FEMA 3062, inombolo ye-FDA 172.515, kunye nenombolo ye-CoE 478, ebonisa ukwamkelwa kwayo kwizicelo zokutya ngaphakathi kweenkqubo zolawulo.

Iimpawu zeMveliso
Iimpawu zeMvelo nezeKhemikhali:

Inkangeleko: Ulwelo olunamafutha olungenambala ukuya kolutyheli (okanye olu-orenji) olukhanyayo.

Iprofayili yevumba: Ibonisa umlinganiswa onamandla, onesalfure kunye ne-caramel etshisiweyo kunye neenothi zekofu eyosiweyo, nangona ichazwa njengenevumba "elibi kakhulu" elitshisiweyo, elinesalfure kwezinye iimeko.

Ukunyibilika: Inyibilika kancinci emanzini kodwa ixutywa nezinyibilikisi zendalo ezifana ne-ethanol kubushushu begumbi.

Izinto ezibalulekileyo eziQinisekisiweyo: Ubuninzi obumalunga ne-1.24-1.255 g/mL; iqondo lokubila limalunga ne-124-129°C.

I-Reactivity: Yikhompawundi ebuthathaka emoyeni efuna ukugcinwa emoyeni ongasebenziyo kwi-2-8°C. Yi-thiol esabela kakhulu ekwaziyo ukwenza ii-covalent bonds ezinamandla kunye neentsimbi ezahlukeneyo.

Iprofayili yoKhuseleko:
Ihlelwe ngokweengxelo zengozi ze-GHS kuquka ukuba inobungozi xa iginyiwe (H302), ukuba yingozi xa idibene nolusu (H312), kunye nokuba yingozi xa iphefumliwe (H332). Idatha yokhuseleko ibonisa ukuba ulusu kunye namehlo anokuba yingozi.

Izicelo eziphambili kunye nobukho beMarike
Ishishini leencasa nevumba
I-Thiophene-2-thiol isebenza njengearhente ephambili yokunambitha kwiimveliso zokutya, ngakumbi kwi:

IiConfections kunye neeBhaka: Kucetyiswa ukuba zisetyenziswe kumanqanaba aphantsi njenge-0.1 mg/kg kwiimveliso zokutya zokugqibela.

Ukuphucula incasa: Inika iincasa ezikhethekileyo ezirostiweyo, ezifana nekharameli kwizinto ezahlukeneyo ezisetyenziswayo.

Izicelo zamayeza
Icandelo leyeza limele indawo ebalulekileyo nekhulayo yokusetyenziswa kwe-thiophene-2-thiol kunye nezinto eziphuma kuyo, ikakhulu ezinje:

Ibhloko Yokwakha Eyenziwe Ngendlela Eninzi: Isebenza njengesixhobo esibalulekileyo sokudibanisa iikhompawundi zamayeza ezintsonkothileyo.

Intsingiselo Eyintloko Yolwakhiwo Ekufumaneni Amayeza: I-thiophene scaffold ixatyiswa ngakumbi ekuphuhliseni amayeza amatsha.

Ityala Elibalaseleyo Lokusetyenziswa Kwamayeza:
Ukusetyenziswa ngokuthe ngqo kweyeza kwe-thiophene-2-thiol derivatives kuboniswe kwiMidesteine ​​(MR-889), iyeza elenzelwe ukunyanga ukukhwehlela kwe-phlegmy. Eli yeza lemolekyuli lincinci, eliquka izinto zesakhiwo ezinxulumene ne-thiophene-2-thiol, lisebenza njengomthinteli we-neutrophil elastase (NE) yomntu. Nangona uphuhliso luye lwayekiswa ngexesha lovavanyo lweSigaba sesi-3, lo mzekelo ugxininisa indlela i-thiophene derivatives enokwakhiwa ngayo ukuze ijolise kwiinkqubo ezithile zesifo.

Uphuhliso loPhando lokuLwa nomhlaza
Izifundo zesayensi zakutshanje zihlolisise izinto eziphuma kwi-thiophene njengezinto ezinokubangela umhlaza:

Ukulungiswa Kwesakhiwo: Abaphandi baye baqulunqa ii-thiophene analogues ezintsha ezibonisa umsebenzi ochasene nomhlaza wesibindi (HepG2) kunye nomhlaza wesibeleko (A2780 kunye ne-A2780CP).

Iziphumo Ezithembisayo: Ezinye izinto eziphuma kuzo, ezifana neekhompawundi ezithile ze-thienopyridine-carboxamide, zibonakalise ukusebenza okulinganayo okanye okuphezulu kuneziyobisi ezisetyenzisiweyo ezifana neSorafenib kwizifundo zokuqala.

Amandla Okusebenza: Ezi khompawundi zimele indlela entsha ethembisayo yophuhliso lwamayeza e-oncology, zisebenzisa isiseko se-thiophene kwiindlela zonyango ezijolise kuzo.

Iipropati ezongezelelweyo zeBiomedical
Ngaphandle kophuhliso oluthile lwamayeza, i-thiophene-2-thiol ineempawu ezininzi ezibalulekileyo kwibhayoloji:

Imisebenzi ye-Antioxidant kunye ne-Anti-inflammatory: Iboniswe kwizifundo ezahlukeneyo.

Iziphumo ze-Antimicrobial: Ibonisa imisebenzi yokulwa neentsholongwane kunye ne-antifungal, nto leyo ebonisa ukuba inokwenzeka ekunyangeni izifo.

I-Metal Chelation: Amandla ayo okubopha iintsimbi ezifana nobhedu, isilivere, negolide angasetyenziswa ekuyileni unyango olujoliswe kwisinyithi okanye iiarhente zokuxilonga.

Izicelo zeSayensi yezinto eziphathekayo kunye noPhando
I-Surface-Enhanced Raman Spectroscopy (SERS): Isetyenziswa njenge-probe kwi-analytical chemistry.

Iimpendulo eziKhathazwa yiMetal: Zisebenza njenge-ligand kwiinkqubo ezahlukeneyo ze-catalytic.

Ukubeka iliso kwiNdalo: Izicelo ezinokubakho ekuphuhliseni iindlela zokulawula ungcoliseko.

Uhlalutyo lweNzuzo yokuthelekisa
Iingenelo ezithile zeThiophene-2-thiol kwindawo yokusetyenziswa
Ukwenziwa kweMithi yezeMithi Iindawo ezisebenzayo ezininzi zivumela utshintsho olwahlukeneyo lweekhemikhali; i-thiophene scaffold inika uzinzo lwe-metabolic kunye neempawu ezilungileyo ze-pharmacokinetic
Ishishini leencasa Impembelelo enamandla yencasa kumanqanaba aphantsi kakhulu (0.1 mg/kg); inika iiprofayili zeemvakalelo ezahlukeneyo ezingafane ziphindwe lula zezinye iikhompawundi
Uphando noPhuhliso Ukusebenza okuphindwe kabini (thiol + heterocycle) kwenza ukusetyenziswa okuhlukeneyo; kusebenza njengebhloko yokwakha izixhobo ezintsha kunye neekhompawundi eziphilayo