Thiophene-2-thiol: Ib qho Molecule uas siv tau ntau yam rau cov tshuaj tsw qab thiab cov tshuaj siv hauv kev lag luam

Thiophene-2-thiol, ib qho tshuaj heterocyclic uas muaj sulfur, tau tsim nws tus kheej ua ib qho molecule uas muaj ntau yam kev siv nrog rau kev siv txij li kev txhim kho saj mus rau kev tsim tshuaj. Paub los ntawm ntau lub npe suav nrog 2-mercaptothiophene thiab 2-thienyl mercaptan, cov tshuaj no qhia txog cov yam ntxwv tshwj xeeb uas ua rau nws muaj txiaj ntsig thoob plaws ntau yam lag luam.

Cov Ntaub Ntawv Tseem Ceeb thiab Txoj Cai Tswjfwm
Cov Tshuaj Txheeb Xyuas: Tus lej CAS: 7774-74-5Cov mis molecular: C₄H₄S₂; Qhov hnyav molecular: 116.2 g / mol.

Kev Pom Zoo Los Ntawm Txoj Cai: Pom zoo ua ib yam khoom qab zib nrog FEMA tus lej 3062, FDA tus lej 172.515, thiab CoE tus lej 478, qhia txog nws qhov kev lees txais hauv cov ntawv thov zaub mov hauv cov qauv kev cai.

Cov yam ntxwv ntawm cov khoom
Cov Khoom Siv Lub Cev thiab Tshuaj:

Tsos: Tsis muaj xim rau daj ntseg (los yog txiv kab ntxwv) oily kua.

Cov Qauv Ntxhiab: Qhia txog tus cwj pwm muaj zog, sulfurous nrog rau cov ntxhiab tsw ntawm burnt-caramel thiab roasted-kas fes, txawm hais tias tau piav qhia tias muaj "tsis zoo heev" hlawv, sulfurous ntxhiab tsw hauv qee qhov xwm txheej.

Kev yaj: Me ntsis yaj hauv dej tab sis sib xyaw nrog cov organic solvents xws li ethanol ntawm chav tsev kub.

Cov Qauv Tseem Ceeb ntawm Lub Cev: Qhov ceev ntawm kwv yees li 1.24-1.255 g/mL; qhov kub npau npau nyob ib puag ncig 124-129°C.

Kev Ua Haujlwm: Ib qho tshuaj uas rhiab rau huab cua uas xav tau kev khaws cia rau hauv huab cua ntawm 2-8 ° C. Nws yog ib qho thiol uas ua haujlwm tau zoo heev uas muaj peev xwm tsim cov kev sib raug zoo nrog ntau yam hlau.

Cov Ntaub Ntawv Kev Nyab Xeeb:
Muab faib ua pawg raws li GHS cov lus qhia txog kev phom sij suav nrog kev phom sij yog tias nqos (H302), kev phom sij thaum kov daim tawv nqaij (H312), thiab kev phom sij yog tias nqus pa (H332). Cov ntaub ntawv kev nyab xeeb qhia txog kev ua rau khaus ntawm daim tawv nqaij thiab qhov muag.

Cov Ntawv Thov Tseem Ceeb thiab Kev Muaj Lag Luam
Kev Lag Luam Qab thiab Tshuaj Tsw Qab
Thiophene-2-thiol ua haujlwm ua tus neeg sawv cev tseem ceeb hauv cov khoom noj, tshwj xeeb tshaj yog hauv:

Khoom qab zib thiab khoom ci: Pom zoo kom muaj tsawg li 0.1 mg/kg hauv cov khoom noj kawg.

Kev Txhim Kho Qab: Muab cov ntxhiab tsw qab zoo li caramel rau ntau yam khoom noj.

Cov Ntawv Thov Tshuaj
Lub chaw muag tshuaj sawv cev rau thaj chaw thov tseem ceeb thiab loj hlob rau thiophene-2-thiol thiab nws cov derivatives, feem ntau yog:

Cov Khoom Siv Ua Vaj Tse Uas Muaj Ntau Yam: Ua haujlwm ua ib qho tseem ceeb hauv kev tsim cov tshuaj sib xyaw ua ke.

Cov Qauv Tseem Ceeb hauv Kev Tshawb Pom Tshuaj: Lub thiophene scaffold muaj nqis ntxiv rau kev tsim cov neeg sawv cev kho mob tshiab.

Cov Kev Siv Tshuaj Tseem Ceeb:
Kev siv tshuaj ncaj qha ntawm thiophene-2-thiol derivatives tau pom tseeb hauv Midesteine ​​(MR-889), ib yam tshuaj uas tsim los kho hnoos phlegmy. Cov tshuaj me me no, uas muaj cov qauv tsim uas cuam tshuam nrog thiophene-2-thiol, ua haujlwm ua tus neeg neutrophil elastase (NE) inhibitor. Txawm hais tias kev tsim kho tau raug tso tseg thaum lub sijhawm sim theem 3, qhov piv txwv no qhia txog yuav ua li cas thiophene derivatives tuaj yeem tsim los tsom mus rau cov txheej txheem kab mob tshwj xeeb.

Kev Txhim Kho Kev Tshawb Fawb Txog Kab Mob Cancer
Cov kev tshawb fawb tsis ntev los no tau tshawb nrhiav cov thiophene derivatives ua cov neeg sawv cev tiv thaiv kab mob qog noj ntshav:

Kev Txhim Kho Cov Qauv: Cov kws tshawb fawb tau tsim cov tshuaj thiophene analogues tshiab uas muaj kev ua haujlwm tiv thaiv kab mob qog noj ntshav siab (HepG2) thiab mob qog noj ntshav zes qe menyuam (A2780 thiab A2780CP) cov kab hlwb.

Cov Txiaj Ntsig Zoo: Qee cov tshuaj derivatives, xws li qee cov tshuaj thienopyridine-carboxamide, tau qhia txog kev ua haujlwm zoo sib xws lossis zoo dua rau cov tshuaj uas tau tsim tsa zoo li Sorafenib hauv kev tshawb fawb ua ntej.

Lub Peev Xwm Mechanistic: Cov tshuaj no sawv cev rau txoj hauv kev tshiab zoo hauv kev tsim tshuaj oncology, siv cov thiophene scaffold rau kev cuam tshuam kho mob.

Cov Khoom Siv Kho Mob Ntxiv
Tshaj li kev tsim cov tshuaj tshwj xeeb, thiophene-2-thiol muaj ntau yam khoom muaj feem cuam tshuam rau lub cev:

Kev Ua Haujlwm Antioxidant thiab Anti-inflammatory: Pom tau hauv ntau txoj kev tshawb fawb.

Cov Kev Ua Haujlwm Tiv Thaiv Kab Mob: Qhia txog ob qho tib si kev ua haujlwm tiv thaiv kab mob thiab fungal, qhia txog lub peev xwm hauv kev kho cov kab mob.

Kev Sib Txuas Hlau: Nws lub peev xwm los khi cov hlau xws li tooj liab, nyiaj, thiab kub tuaj yeem siv rau hauv kev tsim cov kev kho mob uas tsom rau hlau lossis cov neeg sawv cev kuaj mob.

Cov Ntawv Thov Kev Tshawb Fawb Txog Khoom Siv thiab Kev Tshawb Fawb
Surface-Enhanced Raman Spectroscopy (SERS): Siv ua ib qho probe hauv analytical chemistry.

Cov Tshuaj Tiv Thaiv Hlau-Catalyzed: Ua haujlwm ua ligand hauv ntau yam txheej txheem catalytic.

Kev Saib Xyuas Ib Puag Ncig: Tej zaum yuav muaj cov kev siv los tsim cov txheej txheem rau kev tswj kev ua qias tuaj.

Kev Tshuaj Xyuas Qhov Zoo Sib Piv
Cov txiaj ntsig tshwj xeeb ntawm Thiophene-2-thiol hauv daim ntawv thov
Kev Tsim Tshuaj Ntau Yam Qhov chaw ua haujlwm reactive tso cai rau ntau yam kev hloov pauv tshuaj; thiophene scaffold muaj kev ruaj khov ntawm metabolic thiab cov khoom pharmacokinetic zoo
Kev Lag Luam Qab Zib Muaj zog cuam tshuam rau saj ntawm qhov concentration qis heev (0.1 mg/kg); muab cov qauv kev hnov ​​​​​​lus tshwj xeeb uas tsis yooj yim rov ua dua los ntawm lwm cov tshuaj.
Kev Tshawb Fawb & Kev Txhim Kho Ob txoj haujlwm (thiol + heterocycle) ua rau muaj ntau yam kev siv; ua haujlwm ua lub tsev thaiv rau cov ntaub ntawv tshiab thiab cov tshuaj bioactive