Thiophene-2-thiol: Molekyuli Inoshandiswa Pakunhuhwirira Uye Kushandiswa Kwemishonga

Thiophene-2-thiol, chinhu chine sarufa chine heterocyclic compound, chakazvigadzira semorekuru ine zvakawanda zvinoshandiswa kubva pakuvandudza kunaka kusvika pakugadzirwa kwemishonga. Ichizivikanwa nemazita akati wandei anosanganisira 2-mercaptothiophene uye 2-thienyl mercaptan, chinhu ichi chinoratidza hunhu hwakasiyana hunoita kuti chive chakakosha mumaindasitiri akasiyana-siyana.

Ruzivo Rwekutanga uye Mamiriro Ekutonga
Zvinoratidza Makemikari: Nhamba yeCAS: 7774-74-5; Fomura yeMorekuru: C₄H₄S₂; Huremu hweMorekuru: 116.2 g/mol.

Kubvumidzwa Kwemutemo: Kwakatenderwa semushonga wekuwedzera kunaka une nhamba yeFEMA 3062, nhamba yeFDA 172.515, uye nhamba yeCoE 478, zvichiratidza kugamuchirwa kwayo mukushandiswa kwechikafu mukati mehurongwa hwemutemo.

Hunhu hweChigadzirwa
Hunhu hwemuviri nemakemikari:

Chitarisiko: Mvura ine mafuta isina ruvara kusvika yero isina kucheneruka (kana orenji).

Hunhu Hwekunhuwa: Hunoratidza hunhu hwakasimba, hune sarufa ine caramel yakatsva uye kofi yakagochwa, kunyangwe ichitsanangurwa seine hwema "husingafadzi" hwakatsva, hune sarufa mune dzimwe nzvimbo.

Kunyungudika: Inonyungudika zvishoma mumvura asi inogona kusanganiswa nezvinhu zvinonyungudika zvakaita seethanol patembiricha yemumba.

Zvinhu Zvinokosha Zvinoenderana Nemuviri: Kuwanda kwemvura kunosvika 1.24-1.255 g/mL; kufashaira kwemvura kunosvika 124-129°C.

Kushanda kwechinhu: Chinhu chinonzwa mhepo chinoda kuchengetwa mumhepo isina kusimba pa2-8°C. Ichinhu chinoshanda zvakanyanya chinogona kugadzira zvisungo zvakasimba zve covalent nesimbi dzakasiyana-siyana.

Nhoroondo Yekuchengetedza:
Yakarongwa nezviratidzo zvengozi zveGHS zvinosanganisira zvinokuvadza kana zvikamedzwa (H302), zvinokuvadza kana zvasvika paganda (H312), uye zvinokuvadza kana zvafemerwa (H332). Ruzivo rwekuchengetedza runoratidza kuti ganda nemaziso zvinogona kukonzera kusvotwa.

Mashandisirwo Ekutanga uye Kuvapo Kwemusika
Indasitiri yeKunaka neKunhuhwirira
Thiophene-2-thiol inoshanda sechinhu chakakosha mukuwedzera kunaka mune zvekudya, kunyanya mune:

Zvikafu Zvisina Kubikwa: Zvinokurudzirwa pahuwandu hwakaderera se0.1 mg/kg muzvigadzirwa zvekudya zvekupedzisira.

Kuvandudza Kunaka: Inopa zvinonaka zvakasiyana-siyana zvakakangwa, zvakafanana nekaramel kune zvakasiyana-siyana zvinodyiwa.

Mishonga Inoshandiswa
Chikamu chemishonga chinomiririra nzvimbo yakakura uye iri kukura yekushandisa thiophene-2-thiol nezvimwe zvinobva mairi, kunyanya se:

Chivako Chekuvaka Chinosiyana-siyana: Chinoshanda sechikamu chakakosha mukugadzira mishonga yakaoma.

Chinangwa Chepfungwa Yekutanga Mukutsvaga Mishonga: Chigadziko che thiophene chiri kukoshesa zvikuru kugadzira mishonga mitsva yekurapa.

Nyaya Inonyanya Kushandiswa Kwemishonga:
Kushandiswa zvakananga kwemishonga yethiophene-2-thiol derivatives kunoratidzwa muMidesteine ​​(MR-889), mushonga wakagadzirwa kurapa chikosoro chephlegmy. Uyu mushonga mudiki wemorekuru, une zvinhu zvine chekuita nethiophene-2-thiol, unoshanda semushonga wekudzivirira neutrophil elastase (NE) kubva kuvanhu. Kunyangwe kugadzirwa kwacho kwakamiswa panguva yekuyedzwa kwechikamu chechitatu, muenzaniso uyu unoratidza kuti thiophene derivatives dzinogona kugadzirwa sei kuti dzibate maitiro chaiwo ezvirwere.

Kufambira Mberi Kwekutsvaga Kurwisa Gomarara
Ongororo dzesainzi dzichangobva kuitwa dzakaongorora zvinhu zvinogadzirwa nethiophene sezvingangove zvinorwisa kenza:

Kugadzirisa Magadzirirwo Emuviri: Vaongorori vakagadzira mishonga mitsva yethiophene ine simba rakaratidzwa rekurwisa kenza yechiropa (HepG2) uye kenza yemuzai (A2780 neA2780CP).

Mhedzisiro Inovimbisa: Muzvidzidzo zvekutanga, mimwe mishonga inotorwa kubva mumishonga iyi, yakaita semamwe mishonga yethienopyridine-carboxamide, yakaratidza kushanda kwakafanana kana kwepamusoro kune mishonga yagara iripo seSorafenib.

Kugona Kwekugadzira: Mishonga iyi inomiririra nzira itsva inovimbisa mukugadzirwa kwemishonga yekenza, ichishandisa nzira ye thiophene yekurapa kwakanangana.

Zvimwe Zvivakwa zveBiomedical
Kunze kwekugadzirwa kwemishonga chaiyo, thiophene-2-thiol ine zvinhu zvakasiyana-siyana zvine chekuita nehupenyu:

Mabasa eAntioxidant uye Ekudzivirira Kuzvimba: Akaratidzwa muzvidzidzo zvakasiyana-siyana.

Migumisiro yeAntimicrobial: Inoratidza mabasa ekurwisa mabhakitiriya uye antifungal, zvichiratidza mukana wekurapa hutachiona.

Metal Chelation: Kugona kwayo kusunga simbi dzakadai semhangura, sirivha, negoridhe kunogona kushandiswa mukugadzira mishonga inonangwa nesimbi kana mishonga yekuongorora.

Zvishandiso zveSainzi Yezvinhu uye Tsvagiridzo
Surface-Enhanced Raman Spectroscopy (SERS): Inoshandiswa seprobe mu analytical chemistry.

Maitiro Akaita Kuti Zvinhu Zviite Sesimbi: Anoshanda se ligand mumabasa akasiyana-siyana ekugadzirisa zvinhu.

Kutarisa Zvakatipoteredza: Mashandisirwo anogona kuitwa mukugadzira nzira dzekudzora kusvibiswa.

Kuongorora Kubatsira Kwekuenzanisa
Mabhenefiti chaiwo eThiophene-2-thiol munzvimbo yekushandisa
Kugadzirwa kweMishonga Nzvimbo dzakasiyana-siyana dzinoita kuti pave nekuchinja kwakasiyana-siyana kwemakemikari; thiophene scaffold inopa kugadzikana kwemetabolism uye hunhu hwakanaka hwe pharmacokinetic
Indasitiri yeKunaka Kunonaka kwakasimba pahuwandu hwakaderera zvakanyanya (0.1 mg/kg); kunopa ruzivo rwakasiyana rwekunzwa rusingatevedzerwe nyore nemamwe makemikoro.
Tsvagiridzo & Budiriro Mashandiro maviri (thiol + heterocycle) anogonesa mashandisirwo akasiyana-siyana; anoshanda sechivako chezvinhu zvitsva uye mishonga inoshanda mumuviri