Thiophene-2-thiol: He Ngota Whai Hua mō te Kakara me ngā Whakamahinga Rongoā

Tiofene-2-tiorā, he matū heterocyclic kei roto he whanariki, kua whakatūria hei ngota ngota tino maha ngā whakamahinga mai i te whakarei ake i te reka ki te whanaketanga rongoā. E mōhiotia ana i raro i ētahi ingoa tae atu ki te 2-mercaptothiophene me te 2-thienyl mercaptan, e whakaatu ana tēnei matū i ngā āhuatanga ahurei e whai hua ai puta noa i ngā ahumahi maha.

Ngā Mōhiohio Taketake me te Tūnga Ture
Ngā Tāutu Matū: Tau CAS: 7774-74-5; Tātai Ngota: C₄H₄S₂; Taumaha Ngota: 116.2 g/mol.

Whakaaetia e te Ture: Kua whakaaetia hei mea kakara me te nama FEMA 3062, nama FDA 172.515, me te nama CoE 478, e tohu ana i tōna whakaaetia i roto i ngā tono kai i roto i ngā anga ture.

Ngā Āhuatanga o te Hua
Ngā Āhuatanga Ā-tinana me te Matū:

Āhua: Wai hinuhinu, kore tae, ki te kōwhai mārama (karaka rānei).

Āhua Kakara: He kaha te kakara, he whanariki, me ngā kakara karamere tahuna me te kawhe tunua, ahakoa e kiia ana he kakara "tino kino" te kakara, he whanariki tahuna i ētahi horopaki.

Wairewatanga: He tino wairewa noa iho i roto i te wai engari ka taea te whakaranu ki ngā whakarewa waro pēnei i te etanoru i te pāmahana rūma.

Ngā Pūmau Ā-tinana Matua: Te mātotorutanga tata ki te 1.24-1.255 g/mL; te pāmahana kohua tata ki te 124-129°C.

Te Tauhohenga: He matū tairongo-hau e hiahia ana kia rongoatia ki te āhuarangi kore mahi i te 2-8°C. He thiol tino tauhohenga e kaha ana ki te hanga hononga honohono kaha ki ngā momo konganuku.

Kōtaha Haumaru:
Kua whakarōpūtia ki ngā tauākī mōrearea GHS tae atu ki te kino mēnā ka horomia (H302), te kino mēnā ka pā ki te kiri (H312), me te kino mēnā ka manawahia (H332). E tohu ana ngā raraunga haumaru i te tūponotanga o te riri o te kiri me ngā kanohi.

Ngā Taupānga Matua me te Aroaro o te Mākete
Te Ahumahi Reka me te Kakara
He mea nui te Thiophene-2-thiol hei kakara i roto i ngā kai, inā koa i roto i:

Ngā Mea Reka me ngā Kai Tunua: E taunakitia ana kia iti iho i te 0.1 mg/kg te kukū i roto i ngā hua kai whakamutunga.

Whakarei ake i te reka: Ka hoatu he kakara motuhake, rite ki te karamere, ki ngā momo kai e pau ana.

Ngā tono rongoā
Ko te rāngai rongoā he wāhi tono nui, e tipu haere ana hoki mō te thiophene-2-thiol me ōna hua, ko te nuinga hei:

Poraka Hanga Hanganga Maha-Āhua: He takawaenga nui mō te hanga i ngā matū rongoā matatini.

Te Kaupapa Hanganga Matua i roto i te Kitea o te Rongoā: Kei te piki haere te uara o te turanga thiophene mō te whakawhanake i ngā kaihoko rongoā hou.

Te Whakamahinga Rongonui mō te Rongoā:
Kei roto i te Midesteine ​​(MR-889), he rongoā i whakawhanakehia hei rongoā mō te maremare i te mate pāwera, ka whakaaturia te whakamahinga tika o ngā matū thiophene-2-thiol. Ko tēnei rongoā ngota iti, e whakauru ana i ngā āhuatanga hanganga e pā ana ki te thiophene-2-thiol, ka mahi hei aukati i te neutrophil elastase tangata (NE). Ahakoa i mutu te whanaketanga i ngā whakamātautau Wāhanga 3, e whakaatu ana tēnei tauira me pēhea te hanga i ngā matū thiophene hei arotahi ki ngā tikanga mate motuhake.

Ngā Whakatairanga Rangahau Ārai Matepukupuku
Kua tūhuratia e ngā rangahau pūtaiao o nāianei ngā matū thiophene hei rongoā ārai matepukupuku pea:

Arotau Hanganga: Kua hangaia e ngā kairangahau ngā momo thiophene hou kua whakaatuhia te kaha ki te mate pukupuku ate (HepG2) me te mate pukupuku ovarian (A2780 me A2780CP).

Ngā Hua Whakamana: Kua whakaatuhia e ētahi o ngā matū whakaputa, pērā i ētahi matū thienopyridine-carboxamide, he whai huatanga rite, he pai ake rānei ki ngā rongoā kua whakapumautia pērā i te Sorafenib i roto i ngā rangahau tuatahi.

Pūmanawa Ā-tikanga: He huarahi hou whai hua ēnei matū i roto i te whanaketanga o ngā rongoā mate pukupuku, e whakamahi ana i te tūāpapa thiophene mō ngā wawaotanga rongoā kua arotahihia.

Ngā Āhuatanga Hauora Koiora Tāpiri
Haunga te whanaketanga rongoā motuhake, he maha ngā āhuatanga koiora e pā ana ki te thiophene-2-thiol:

Ngā Mahi Ārai-Hōhā me te Ārai-Mumura: Kua whakamātauhia i roto i ngā rangahau maha.

Ngā Pānga Paturopi: E whakaatu ana i ngā mahi patu huakita me ngā mahi patu harore, e whakaatu ana i te kaha ki te rongoā i ngā mate pāwera.

Te Whakapūmau i te Konukura: Ko tōna kaha ki te here i ngā konganuku pēnei i te parahi, te hiriwa, me te koura ka taea te whakamahi hei hoahoa i ngā maimoatanga e aro ana ki te konganuku, i ngā kaihoko tātaritanga rānei.

Ngā Taupānga Pūtaiao Rauemi me te Rangahau
Te Matawai Raman Whakarei-Mata (SERS): Whakamahia hei ine i roto i te matū tātari.

Ngā Tauhohenga Whakakorikori-Metara: Ka mahi hei ligand i roto i ngā tukanga whakakorikori maha.

Aroturukitanga Taiao: Ngā tono pea hei whakawhanake i ngā tikanga mō te whakahaere parahanga.

Tātari Painga Whakataurite
Ngā Painga Motuhake mō te Rohe Whakamahinga o te Thiophene-2-thiol
Te Hanga Rongoā Ka taea e ngā pae tauhohe maha te whakarerekē i ngā matū rerekē; ka tukuna e te hanganga thiophene te pumau o te pākia me ngā āhuatanga pharmacokinetic pai.
Te Ahumahi Reka He pānga reka kaha i ngā kukū tino iti (0.1 mg/kg); e whakarato ana i ngā āhua rongo motuhake e kore e ngāwari te tāruarua e ētahi atu matū
Rangahau me te Whakawhanaketanga Ngā mahi takirua (thiol + heterocycle) e āhei ai ngā tono kanorau; hei poraka hanga mō ngā rauemi hou me ngā matū koiora