Thiophene-2-thiol: Molekuli ikoreshwa mu buryo butandukanye mu gutanga impumuro nziza no mu miti

Thiophene-2-thiol, imvange irimo sulfur heterocyclic, yigaragaje nk'imvange ikora ibintu byinshi bitandukanye, ikaba ikoreshwa kuva ku kongera uburyohe kugeza ku iterambere ry'imiti. Iki kivange kizwi ku mazina menshi arimo 2-mercaptothiophene na 2-thienyl mercaptan, kigaragaza imiterere yihariye ituma kigira agaciro mu nganda nyinshi.

Amakuru y'ibanze n'imiterere y'amategeko
Ibiranga imiti: Nimero ya CAS: 7774-74-5; Formula ya Molecular: C₄H₄S₂; Uburemere bwa Molecular: 116.2 g/mol.

Kwemezwa n'amategeko: Byemejwe nk'umuti wo gusiga ibirungo hamwe na FEMA nomero 3062, FDA nomero 172.515, na CoE nomero 478, bigaragaza ko byemewe mu ikoreshwa ry'ibiribwa mu buryo bw'amategeko.

Ibiranga Ibicuruzwa
Imiterere y'umubiri n'imiti:

Ishusho: Ikiyiko cy'amavuta kidafite ibara cyangwa umuhondo werurutse (cyangwa orange).

Imiterere y'impumuro mbi: Igaragaza imiterere ikomeye, ifite sulfure hamwe na karameli yahiye n'ikawa yokejwe, nubwo bivugwa ko ifite impumuro "ibabaje cyane" yahiye, ifite sulfure mu bihe bimwe na bimwe.

Gushonga: Bishongera gato mu mazi ariko bivangwa n'ibintu bishongera umwimerere nka ethanol ku bushyuhe bw'icyumba.

Ibipimo by'ingenzi by'umubiri: Ubucucike buri hagati ya 1.24 na 1.255 g/mL; ubushyuhe buri hagati ya 124 na 129°C.

Gusubiramo: Ikinyabutabire gikenera ikirere kidahumeka gikenera kubika ahantu hadahumeka kuri dogere selisiyusi 2-8. Ni thiol ishobora gukorana cyane n'ibyuma bitandukanye.

Umwirondoro w'umutekano:
Ishyirwa mu byiciro bya GHS birimo ingaruka mbi iyo umuntu ayimize (H302), ingaruka mbi iyo ayikoze ku ruhu (H312), n'ingaruka mbi iyo ayihumetse (H332). Amakuru y'umutekano agaragaza ko uruhu n'amaso bishobora gutera ububabare.

Porogaramu z'ibanze n'uko isoko riboneka
Inganda zitunganya uburyohe n'impumuro nziza
Thiophene-2-thiol ikora nk'ikintu cy'ingenzi mu gusiga uburyohe mu biribwa, cyane cyane muri:

Ibiryo bivanze n'ibiryo bitekeshejwe: Bisabwa ku gipimo kiri hasi cya 0.1 mg/kg mu biribwa bya nyuma.

Kongera uburyohe: Itanga uburanga bwihariye bumeze nk'ubwa karameli ku biryo bitandukanye biryoshye.

Imikoreshereze y'imiti
Urwego rw'imiti rugaragaza igice gikomeye kandi gikomeje kwiyongera cy'ikoreshwa rya thiophene-2-thiol n'ibiyikomokaho, cyane cyane nka:

Inyubako y’Ubuvanganzo ikoreshwa mu buryo butandukanye: Ikora nk'igikoresho cy'ingenzi mu gukora imiti ivanze.

Impamvu nyamukuru mu kuvumbura imiti: Urukuta rwa thiophene rurushaho guhabwa agaciro mu gukora imiti mishya.

Urugero rw'Ikoreshwa ry'Imiti Rizwi:
Uburyo imiti ikomoka kuri thiophene-2-thiol ikoreshwa mu buryo butaziguye bwagaragajwe muri Midesteine ​​(MR-889), umuti wakorewe kuvura inkorora y'umusonga. Uyu muti muto, urimo ibintu by'imiterere bifitanye isano na thiophene-2-thiol, ukora nk'umuti ubuza abantu kwandura neutrophil elastase (NE). Nubwo iterambere ryahagaritswe mu gihe cy'igeragezwa rya 3, uru rugero rugaragaza uburyo imiti ikomoka kuri thiophene ishobora guhindurwa kugira ngo yibasire uburyo bwihariye bw'indwara.

Iterambere ry'ubushakashatsi ku kurwanya kanseri
Ubushakashatsi bwa siyansi buherutse gukorwa bwagaragaje ko ibikomoka kuri thiophene bishobora kurwanya kanseri:

Kunoza Imiterere y'Inyubako: Abashakashatsi bakoze ubwoko bushya bwa thiophene bugaragaza imikorere yabwo mu kurwanya kanseri y'umwijima (HepG2) na kanseri y'intanga ngore (A2780 na A2780CP).

Ibisubizo Bishimishije: Hari imiti imwe n'imwe ikomoka kuri thienopyridine-carboxamide, yagaragaje ko ishobora kugereranywa cyangwa irusha izindi miti yamenyekanye nka Sorafenib mu bushakashatsi bw'ibanze.

Ubushobozi bwa Mechanistic: Iyi miti igaragaza inzira nshya yizewe mu iterambere ry'imiti ya kanseri, ikoresheje urwego rwa thiophene mu bikorwa byihariye byo kuvura.

Indi miterere y'ubuvuzi
Uretse iterambere ry’imiti yihariye, thiophene-2-thiol ifite imiterere myinshi ijyanye n’ibinyabuzima:

Ibikorwa byo kurwanya ogisijeni n'ibikorwa byo kurwanya ububyimbirwe: Byagaragajwe mu bushakashatsi butandukanye.

Ingaruka zo kurwanya mikorobe: Igaragaza ibikorwa byo kurwanya mikorobe no kurwanya mikorobe, bigaragaza ko ishobora kuvura indwara zandura.

Chelation y'icyuma: Ubushobozi bwayo bwo gufatanya ibyuma nk'umuringa, ifeza, na zahabu bushobora gukoreshwa mu gushushanya uburyo bwo kuvura bugamije icyuma cyangwa imiti ivura indwara.

Porogaramu za Siyansi y'Ibikoresho n'Ubushakashatsi
Spectroscopy ya Raman Iterambere mu Buso (SERS): Ikoreshwa nk'isuzuma mu buhanga bwa chimie.

Uburyo bwo gukora ibintu hakoreshejwe ibyuma: Ikora nk'umuyoboro mu buryo butandukanye bwo gukora ibintu hakoreshejwe ibyuma.

Gukurikirana ibidukikije: Ikoreshwa rishoboka mu gutegura uburyo bwo kurwanya ihumana.

Isesengura ry'Ibyiza Bigereranijwe
Agace gakoreshwamo Ibyiza byihariye bya Thiophene-2-thiol
Uburyo bwo gukora imiti Ahantu hakoreshwa uburyo butandukanye bwo guhindura ibintu mu buryo bw’imiti hatuma habaho impinduka zitandukanye mu buryo bw’imiti; urwego rwa thiophene rutanga ubushobozi bwo guhagarara neza mu mikorere y’imiti n’imiterere myiza mu bijyanye n’imiti.
Inganda z'uburyohe Ingaruka zikomeye z'uburyohe ku gipimo gito cyane (0.1 mg / kg); itanga imiterere yihariye y'ibyumviro idashoboka gukopeshwa n'ibindi bintu.
Ubushakashatsi n'Iterambere Imikorere ibiri (thiol + heterocycle) ituma habaho ikoreshwa ritandukanye; ikora nk'inkingi y'ubwubatsi bw'ibikoresho bishya n'ibinyabutabire bikora ku buzima