I-Thiophene-2-thiol: I-Molecule Ehlukahlukene Yephunga Nezicelo Zemithi

I-Thiophene-2-thiol, i-compound equkethe i-sulfur heterocyclic, izibonakalise njenge-molecule eguquguqukayo kakhulu enezinhlelo zokusebenza ezisukela ekuthuthukisweni kokunambitheka kuya ekuthuthukisweni kwemithi. Njengoba yaziwa ngamagama amaningana kufaka phakathi i-2-mercaptothiophene kanye ne-2-thienyl mercaptan, le compound ikhombisa izakhiwo ezihlukile ezenza ibe yigugu ezimbonini eziningi.

Ulwazi Oluyisisekelo kanye Nesimo Sokulawula
Izikhombisi Zamakhemikhali: Inombolo ye-CAS: 7774-74-5Ifomula Yamamolekyuli: C₄H₄S₂; Isisindo Samamolekyuli: 116.2 g/mol.

Ukuvunyelwa Okusemthethweni: Kuvunyelwe njenge-ejenti yokunambitha enenombolo ye-FEMA 3062, inombolo ye-FDA 172.515, kanye nenombolo ye-CoE 478, okubonisa ukwamukelwa kwayo ekusetshenzisweni kokudla ngaphakathi kwezinhlaka zomthetho.

Izici Zomkhiqizo
Izakhiwo Zomzimba Nezamakhemikhali:

Ukubukeka: Uketshezi olunamafutha olungenambala kuya koluphuzi olukhanyayo (noma olu-orenji).

Iphrofayili Yephunga: Ibonisa umlingiswa onamandla, onesibabule one-caramel eshisiwe kanye namanothi ekhofi eyosiwe, naphezu kokuchazwa njengenephunga "elibi kakhulu" elishisiwe, elinesibabule kwezinye izimo.

Ukuncibilika: Kuncibilika kancane emanzini kodwa kungaxutshwa nezinyibilikisi eziphilayo ezifana ne-ethanol ekushiseni kwegumbi.

Ama-Key Physical Constants: Ubuningi obungaba ngu-1.24-1.255 g/mL; iphuzu lokubila elizungeze u-124-129°C.

Ukusabela: Inhlanganisela ezwela umoya edinga isitoreji somoya esingasebenzi kahle ku-2-8°C. Iyi-thiol esabela kakhulu ekwazi ukwakha izibopho eziqinile ze-covalent nezinsimbi ezahlukahlukene.

Iphrofayili Yokuphepha:
Kuhlukaniswe ngezitatimende zengozi ze-GHS kufaka phakathi okulimazayo uma kugwinyiwe (H302), okulimazayo uma kuthintana nesikhumba (H312), kanye nokulimaza uma kuphefumulwa (H332). Imininingwane yokuphepha ikhombisa ukuthi kungenzeka yini ukucasuka kwesikhumba namehlo.

Izicelo Eziyinhloko kanye Nokuba Khona Kwemakethe
Imboni Yokunambitheka Nephunga
I-Thiophene-2-thiol isebenza njenge-ejenti eyinhloko yokunambitheka emikhiqizweni yokudla, ikakhulukazi ku:

Ama-Confection kanye Nezinto Ezibhakiwe: Kunconywa ngamanani aphansi njengo-0.1 mg/kg emikhiqizweni yokudla yokugcina.

Ukuthuthukisa Ukunambitheka: Kunikeza amanothi ahlukile athosiwe, afana ne-caramel ezitsheni ezahlukahlukene ezidliwayo.

Izicelo Zemithi
Umkhakha wezokwelapha umele indawo ebalulekile nekhulayo yokusetshenziswa kwe-thiophene-2-thiol kanye nezinto eziphuma kuyo, ikakhulukazi njenge:

Isakhiwo Sokwenziwa Esiguquguqukayo: Sisebenza njengesikhungo esibalulekile ekwakhiweni kwamakhemikhali emithi ayinkimbinkimbi.

Inhloso Yesakhiwo Esiyinhloko Ekutholakaleni Kwezidakamizwa: I-scaffold ye-thiophene iya ngokuya ithandwa kakhulu ekuthuthukiseni ama-ejenti amasha okwelapha.

Icala Elivelele Lokusetshenziswa Kwemithi:
Ukusetshenziswa kwemithi okuqondile kwe-thiophene-2-thiol derivatives kuboniswe ku-Midesteine ​​(MR-889), umuthi owenzelwe ukwelapha ukukhwehlela kwe-phlegmy. Lo muthi omncane we-molecule, ohlanganisa izakhi zesakhiwo ezihlobene ne-thiophene-2-thiol, usebenza njengomvimbeli we-neutrophil elastase (NE) yomuntu. Nakuba ukuthuthukiswa kwamiswa ngesikhathi sokuhlolwa kweSigaba sesi-3, lesi sibonelo siqokomisa indlela i-thiophene derivatives engaklanywa ngayo ukuze iqondise izindlela ezithile zesifo.

Intuthuko Yocwaningo Lokulwa Nomdlavuza
Izifundo zesayensi zakamuva zihlole izidakamizwa ze-thiophene njengezinto ezingaba khona zokulwa nomdlavuza:

Ukuthuthukiswa Kwesakhiwo: Abacwaningi bahlanganise ama-analogue amasha e-thiophene anomsebenzi obonisiwe wokulwa nomdlavuza wesibindi (HepG2) kanye nomdlavuza wesibeletho (A2780 kanye ne-A2780CP).

Imiphumela Ethembisayo: Ezinye izinto ezisetshenziswayo, njengezinye izinto ezisetshenziswayo ze-thienopyridine-carboxamide, zibonise ukusebenza kahle okufana noma okuphezulu kunemithi ekhona njengeSorafenib ezifundweni zokuqala.

Amandla Okusebenza: Lawa ma-compound amelela indlela entsha ethembisayo ekuthuthukisweni kwemithi yomdlavuza, esebenzisa isikafu se-thiophene sokungenelela okuqondiwe kokwelapha.

Izakhiwo Ezingeziwe Zezokwelapha
Ngaphandle kokuthuthukiswa kwemithi ethile, i-thiophene-2-thiol ibonisa izakhiwo eziningana ezibalulekile zemvelo:

Imisebenzi Yokulwa Nokulwa Nokuvuvukala: Kuboniswe ezifundweni ezahlukahlukene.

Imiphumela Yokulwa Namagciwane: Ibonisa kokubili imisebenzi yokulwa namagciwane kanye neyokulwa namagciwane, okubonisa ukuthi kungenzeka ekwelapheni izifo.

I-Metal Chelation: Ikhono layo lokubopha izinsimbi ezifana nethusi, isiliva, negolide lingasetshenziswa ekwakheni izindlela zokwelapha eziqondiswe kunsimbi noma izinto zokuxilonga.

Izicelo Zesayensi Yezinto Ezibalulekile Nocwaningo
I-Surface-Enhanced Raman Spectroscopy (SERS): Isetshenziswa njenge-probe ku-analytical chemistry.

Ukusabela Okubangelwa Yinsimbi: Kusebenza njenge-ligand ezinqubweni ezahlukahlukene zokuvuselela amandla.

Ukuqapha Imvelo: Izicelo ezingaba khona ekuthuthukiseni izindlela zokulawula ukungcola.

Ukuhlaziywa Kwezinzuzo Eziqhathaniswayo
Izinzuzo Ezikhethekile Zendawo Yokusetshenziswa Ye-Thiophene-2-thiol
Ukwenziwa Kwemithi Izindawo ezisebenzayo eziguquguqukayo zivumela ukuguqulwa kwamakhemikhali okuhlukahlukene; i-thiophene scaffold inikeza ukuzinza kwe-metabolic kanye nezakhiwo ezinhle ze-pharmacokinetic
Imboni Yokunambitheka Umthelela wokunambitheka onamandla ekugxilweni okuphansi kakhulu (0.1 mg/kg); unikeza amaphrofayili ezinzwa ahlukile angaphindaphindwa kalula ngamanye amakhemikhali
Ucwaningo Nokuthuthukiswa Ukusebenza okuphindwe kabili (i-thiol + i-heterocycle) kwenza izinhlelo zokusebenza ezahlukahlukene; kusebenza njengesisekelo sezinto ezintsha kanye namakhemikhali asebenzayo