Premium 2,5-Hexanedione (CAS 110-13-4) for Pharmaceutical & Polymer Synthesis

Chemical name：2,5-Hexanedione

Synonyms: Hexan-2,5-Dion; hexane-2,5-dione; Acetonylacetone

Molecular weight: C₆H₁₀O₂

Appearance: Clear light brown liquid

Stability : 1. Do not contact with strong oxidants, strong reducing agents, and strong alkali. The boiling point is high, the steam is low, and it is usually safer to use under normal conditions, but it is still necessary to pay attention to fire prevention. It can be miscible with water, ethanol and ether, but not with hydrocarbon solvents. It is also insoluble in concentrated potassium hydroxide or potassium carbonate solutions. It can dissolve polymethyl methacrylate, polystyrene, polyvinyl acetate, vinyl chloride and vinyl acetate copolymer, cellulose nitrate, phenolic resin and other synthetic resins as well as rosin, conch rosin, grease and other natural resins. It can partially dissolve shellac, dewaxed dama resin, glycerin trirosin ester, cottonseed oil, etc.

2. Chemical properties: The general reaction of ketones. It reacts with diphosphorus pentasulfide to form 2, 5-dimethylthiophene. 2, 5-dimethylpyrrole is formed when it is reacted with an alcohol-ammonia solution or heated with ammonium carbonate. Dehydration produces 2, 5-dimethylfuran. It reacts with 2, 4-dinitrophenylhydrazine to form bis (2, 4-dinitrophenyl) hydrazone with a melting point of 257 ° C.

3. It exists in flue-cured tobacco leaves and smoke.

4. Moderate local stimulant, high concentration causes anesthesia.

2,5-Hexanedione serves as a valuable versatile building block and key precursor in modern pharmaceutical synthesis. Its symmetrical diketone structure, featuring two reactive carbonyl groups, makes it a crucial intermediate for constructing complex heterocyclic and cyclic compounds central to many active pharmaceutical ingredients (APIs).

Its primary pharmaceutical applications include:

Synthesis of Heterocyclic Scaffolds: 2,5-Hexanedione is fundamentally used in the Paal-Knorr synthesis to produce substituted furans and pyrroles. These five-membered heterocyclic rings are privileged structures in medicinal chemistry, forming the core of numerous drugs with diverse biological activities (e.g., antimicrobial, anti-inflammatory, kinase inhibitory).

Production of Pyrrole Derivatives: Through condensation with primary amines, 2,5-Hexanedione efficiently yields 2,5-dimethylpyrrole and its derivatives. These pyrroles are themselves key intermediates for further functionalization into more complex molecules used in pharmaceutical research and development.

Precursor to Cyclic Compounds: The compound can undergo intramolecular reactions to form cyclohexenone derivatives, which are important intermediates for synthesizing steroidal frameworks and other pharmacologically relevant cyclic systems.

Intermediate for Specialty Chemicals: It acts as a starting material in the synthesis of more advanced chemical intermediates that are incorporated into final drug substances targeting a range of therapeutic areas, including central nervous system (CNS) disorders and infectious diseases.

Due to its role in these critical synthetic pathways, 2,5-Hexanedione is specified in the manufacturing processes for several generic APIs and investigational new drugs. Our high-purity grade ( >99%) ensures consistency, low impurity profiles, and compliance with the stringent quality standards required for pharmaceutical GMP manufacturing, supporting reliable scale-up from research to commercial production.

1.High purity 99.0%min

2.Use a wide range of taste.

3.We have ISO 9001 ,ISO 14001 and ISO22000 certificate , We also have HACCP certificate ,have Halal and kosher certificate of this product.

5. We have a big capacity ,so, commonly have fast lead time.

6. We can offer 10g-50g free sample for your lab test .we commonly delivery the sample by international courier like DHL or Fedex. It is fast and convenient.

1.The sample packing is 20g/30g/50g per bottle.

2.The small packing is 1kg /5kg /10 kg per bottle.

3.25 kg per drum(Food grade plastic drum, plasticizer free, third-party certification report)

Packaging can also be customized according to customer needs